Sudora Sense

The Sudora Sense

The Sudora Sense is unlike any other medical product.

We emphasize the importance of simple and straightforward solutions by using emerging technology to create an efficient, cost-effective and reliable solution that will impact millions. In short, the Sudora Sense non-invasively collects sweat to analyze protein concentration levels and quickly diagnose a patient with a bacterial or viral infection, or no infection at all.

The Sudora solution relies on adequate and efficient sweat collection, which is why we have taken sweat gland location and sweat collection material into consideration.

The Sudora Sense collects sweat from the eccrine glands of the palm, producing up to 30 grams of sweat per minute, as the patient simply places their hand on the platform. The analysis technology being used requires around 10 grams of sweat, as per the 96-well plate ELISA kit that requires 100 microlitres per well.

To ensure that the sweat is effectivity collected, regardless of the sweating tendencies of each patient, the simple sweat induction technique of steam exposure will be used in our device. Water produced from the filtration process would be converted into steam, which slightly increases body temperatures and opens sweat pores on the palm.

As the palm of the patient’s hand sweats, a sheet of carbon textile, derived from silk fabric, will effectively collect the substance. To enhance conductivity and modulate the semiconductor’s output, the material will be N-doped by adding small amounts of arsenic or phosphorus (harmless in small quantities). The textile’s high wettability (ability to absorb sweat for the transmission of electrons) and porous structure for electrical conductivity makes it the ideal and most effective source of sweat collecting material.

Sweat is 99% water, meaning the total protein concentration is only around 0.10 to 0.25 microgram per microlitre. In order to analyze this small amount, the water in the sweat must be filtered, thereby dividing it from the proteins and other chemicals.

The second layer of the Sudora Sweat will be made up of small dialysis tubing. With its semipermeable membrane, the tubing will be able to perform osmosis to separate the water from the other substances.

As the chemicals and proteins would move on to the next stage of analysis, the filtered water is exposed to heat and converted into water vapour, to be then used as renewable energy for the device’s source of energy (by using the water’s friction to generate energy), as well as an induction method for sweat.

Based on past research and clinical trials, there are several specific proteins that can be associated with viral or bacterial infections based on their concentration levels. To ensure specificity and prevent false-positive/negative results, the Sudora Sense looks at 4 specific proteins; Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), Procalcitonin (PCT), C-Reactive Protein (CRP) and Interferon gamma-induced protein 10 (IP-10).

Essentially, there are higher contraction levels of TRAIL CRP2 and IP-10 when the patient is virally infected, and higher concentration levels of PCT and CRPv in patients with bacterial infections.

The TLip-LISA (temperature-responsive liposome-linked immunosorbent assay) essentially uses specific nanoparticles (microscopic particles) that respond to certain stimuli (a change that triggers a corresponding reaction).

In the TLip-LISA, the nanoparticles used are liposomes — vesicles that are commonly used for drug delivery. Instead of carrying drugs, the liposome carries fluorophores. These small molecules use excitation and the ability to absorb light and re-emit it in longer wavelengths, to perform antibody conjugation, which is the process of chemically labelling an antibody.

Once the molecules have been identified, the nanoparticles must gain information regarding the protein concentration levels in order to determine whether the infection is viral or bacterial. To do this, the liposomes contain a fluorescent dye known as SQR22 which after sensing a temperature change, uses its temperature-responsive characteristics to help the molecule diffuse from its gel state to a liquid crystalline state. This point when the temperature and state of the liposome change are known as the inflection time point, and contains the data that identifies whether or not the pathogens are present and whether they are bacterial or viral.

After all the data has been collected and labelled using TLip-LISA technology, a fluorescence detector will be used to read the signal for analysis. To diagnose the patient, a custom algorithm will be inputted into the device along the lines of:

M(viral) or M(bacterial) = x with considerations to [C], [P], [G] and [T]

(when M = microbes, x = units according to the concentration levels of each protein in sweat, C = CRP, P = PCT, G = IP-10 and T = TRAIL).

Because the field of protein and biomarker research in sweat has only started to grow, clinical trials must take place to determine the concentration levels of each protein in sweat from a diverse sample. These tests will be conducted by Sudora with similar methods to previous trials that determined the concentration levels in blood and urine.

Once the data goes through the mathematical formula, a percentage will be calculated to determine the probability of the infection being viral or bacterial. From here, the input signal will be displayed as the test results on the Sudora Sense’s active display screen for the patient and/or medical professional to read.

Faqs

Frequently Asked Questions

Better Than Ever Before

The Sudora Sense can be used as frequently as the patient wants, meaning a test can be run every day or only when feeling symptomatic. Doctors should use the device on patients before prescribing antibiotics to ensure they are necessary.

The Sudora Sense will be available at clinics and hospitals throughout the United States, as well as local pharmacies. It will also be available for purchase over-the-counter for patient use at home.

Our technology is non-invasive, meaning the test is performed by simply scanning your hand. The palm usually generates enough sweat for analyses (around 10 grams is needed), however, simple induction methods like presenting small amounts of steam also work. No need to do a workout to produce sweat!

The Sudora Sense introduces brand new technology and science that are 10 times better than anything we have today, in accuracy (measured in folds ), efficiency (non-invasive and quick) and death/infection prevention levels.

Although most of Sudora Sense is developed with emerging technology that has yet to be widely sold, we estimate that manufacturing costs for the device will be around $150. With an average markup of 50%, Sudora can be profitable by selling the Sense for $200-$225 each. Based on the wearable technology and health-monitoring market, we believe that this is a reasonable and cost-efficient price, with Apple Watches costing more than $250, glucose monitors costing up to $1,000 per year and blood test lab kits ranging anywhere from $500-$5,000 (or more).

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